3D Skin Model Project

Organoid structures resembling the 3D architecture of tissue and made from human primary cells take over the research land scape since some years already. 
The unique deposition of pigments into the dermal layer of the skin during tattooing makes 3D tattooed skin models (TatS) indispensible for studying tattoo toxicology. 

Currently, the models are used to study the UV-pigment interaction and its effect on skin cells. 

Biodistribution of tattoo ink ingredients

Until now, the amount of ink and by this the exposure per cm² was never accuratly assessed. 
In current projects, we aim to determine the amount of ink used and the distribution of soluble ingredients in the human body directly after tattooing. 

Tattoo Allergy Project

Delayed type like tattoo allergic reactions are most frequent with red color shades. Until recently, no study characterized the pigments inside the skin of tattoo allergy patients to find the source of these reactions. Also, since pigments are practically insoluble and thus biologically inert, the allergic substance is thought to be an impurity, decomposition product or metabolite of the pigments used. The aim of this project is to find the true allergen causing these reactions.